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基于中医药传承辅助平台研究治疗老年痴呆与血管性痴呆方剂的组方用药差异
Study on the difference of prescriptions for the treatment of Alzheimer"s disease andVascular dementia based on the Chinese Medicine Heritage Auxiliary Platform
投稿时间:2018-12-09  修订日期:2018-12-09
DOI:
中文关键词:  老年痴呆  血管性痴呆  方剂  配伍规律
英文关键词:Alzheimer’s disease  Vascular dementia  Prescription  Compatibility regularity
基金项目:
作者单位E-mail
文跃强 成都中医药大学基础医学院 wenyueqiang@163.com 
付颖 成都中医药大学中医脑病药物整合转化研究所  
魏江平 成都中医药大学中医脑病药物整合转化研究所  
陈欢 成都中医药大学中医脑病药物整合转化研究所  
代渊 成都中医药大学基础医学院  
徐世军 成都中医药大学中医脑病药物整合转化研究所 daniya5@sina.com 
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中文摘要:
      【】目的:基于中医传承辅助平台(V2.5)软件分析近5年期刊文献中治疗老年痴呆与血管性痴呆方剂的组方用药差异,寻找其组方用药规律。方法:筛选CNKI、VIP、万方数据库中近5年来治疗老年痴呆与血管性痴呆的方剂,通过中医传承辅助平台(V2.5)软件构建方剂数据库,利用该软件集成的关联规则及熵聚类等数据挖掘算法,比较治疗老年痴呆和血管性痴呆方剂中的用药频次、药物性味归经、常用药对、潜在药对及挖掘得到新方的差异。结果:老年痴呆和血管性痴呆方剂中前20位高频使用中药中共13味一致,各有7味不同。同主要体现了虚瘀痰互结为二者的共有病机,异体现了老年痴呆以脾肾亏虚、精血不足为病机侧重点,而血管性痴呆以痰瘀互阻、浊毒阻络为病机侧重点;性味二者均以温药为主,但老年痴呆以甘温为主,其次为平性和寒性,血管性痴呆以苦温为主,其次为寒性和平性;归经均以肝经为主,其次依次为心经、脾经和肾经,具有一致性;此外挖掘分别发现了潜在药对和新方分别为16个、7个和26个、13个。结论:老年痴呆与血管性痴呆处方用药同中有异,各有侧重,提示前者治疗重在温阳健脾,后者重在化痰逐瘀、泄毒醒脑。
英文摘要:
      Objective: Based on the Chinese Medicine Heritage Auxiliary Platform (V2.5) software, to analyze the differences in prescriptions for the treatment of Alzheimer"s disease and Vascular dementia in the literature of the past five years, and to find the rules of prescription. Methods: Screening CNKI, VIP, and Wan fang data for nearly 5 years to find the prescriptions for the treatment of Alzheimer"s disease and Vascular dementia, and constructing a prescription database through the Chinese Medicine Heritage Auxiliary Platform (V2.5) software, and utilizing the Data mining algorithms such as association rules and entropy clustering of the software. Compare the frequency of medication, the drug’s natural, flavour and channel tropism, the common drug pairs, the potential drug pairs, and the differences in the new prescriptions used in the treatment of senile dementia and vascular dementia. Results:13 of the top 20 high frequency herbs used in AD and VD are the same, the other is different. It common pathogenesis reflect the interaction of deficiency, stasis and phlegm, while the difference shows that AD focuses on spleen and kidney deficiency, insufficiency of essence and blood, but VD focuses on the interaction of phlegm blood stasis and toxic turbidity obstruction in collaterals. They both use warm herbs in nature and flavour, but AD mainly use sweet and warm herbs, followed by calm and cold herbs, while VD mainly use bitter and warm herbs, followed by cold and calm herbs; The channel tropisms both are mainly liver channel, followed by heart channel, spleen channel and kidney channel. In addition,16 potential medicine pairs, 7 new prescriptions, 26 new prescriptions and 13 new prescriptions were found. Conclusion: Prescriptions for AD and VD have similarities and differences, with emphasis on each other, suggesting that the former focuses on warming Yang and invigorating spleen, while the latter focuses on resolving phlegm and removing blood stasis, detoxifying and awakening the brain.
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