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藏药余甘子鞣质部位主要药效成分在人工胃肠液中的稳定性研究
Research on Stability of Tannin Part in Phyllanthus emblica L. in Artificial Gastric And Intestinal Juice
  
DOI:
中文关键词:  关键词:余甘子 鞣质部位 人工胃、肠液 稳定性
英文关键词:Keywords: Phyllanthus emblica L., tannin part, artificial gastric and intestinal juice, stability
基金项目:
作者单位
吴玲芳,叶婷,梁林金,梁文仪,陈文静,李 师,崔亚萍,亓 旗,张兰珍 北京中医药大学中药学院 北京 100102 
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中文摘要:
      摘 要:目的:研究余甘子鞣质部位主要药效成分在人工模拟胃、肠液中的稳定性,为余甘子体内代谢研究提供依据。方法:采用人工模拟胃液、肠液,体外温孵,HPLC-UV法测定余甘子鞣质部位中主要药效成分的含量变化情况;分别考察余甘子鞣质部位主要药效成分在人工胃肠液中的稳定性。结果:余甘子鞣质部位中主要药效成分没食子酸、柯里拉京、鞣花酸在人工胃液中比较稳定,含量变化不明显,降解剩余量在100%左右波动,半衰期大于90h;在人工肠液中不稳定,含量先增加后减少,降解剩余量在100-300%之间波动,半衰期大于10h。结论:余甘子鞣质部位主要药效成分在人工胃液中比较稳定,各成分含量变化不明显;余甘子鞣质部位主要药效成分在人工肠液中不稳定,主要成分含量先增加后减少,推测大分子可水解鞣质可以转化成小分子成分,但是随着时间延长所有成分均在降解。
英文摘要:
      Abstract: This article was aimed to study the stability of tannin parts in Phyllanthus emblica L. in artificial gastric and intestinal juice, in order to provide a foundation for in vivo studies of Phyllanthus emblica L. HPLC-UV was used to determine the contents of main ingredients. The results showed that stability of main ingredients of tannin parts in Phyllanthus emblica L., including gallic acid (GA), corilagin and ellagic acid (EA), in the artificial gastric juice. The content change was not obvious. The residual content was within 100%. The half-life was above 90 h. They were unstable in the artificial intestinal juice. The content was first increased and then decreased. The residual content was 100-300%. The half-life was above 10 h. It was concluded that the tannin parts in Phyllanthus emblica L. was stable in artificial gastric juice. And content changes of main components were not obvious. The tannin parts in Phyllanthus emblica L. were unstable in artificial intestinal juice. The main ingredients were first increased and then decreased. It was speculated that macromolecule can hydrolyze tannin part into small molecules. However, as time increases, all components may be decomposed.
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