Objective To explore the pathogenesis and treatment of new coronavirus pneumonia in Guangdong. Methods The four diagnostic data of confirmed cases in our hospital were collected since the outbreak of new coronary pneumonia in December 2019, then combined with our past experience in the treatment of epidemic diseases and summary of relevant literatures. Results .The pathological factors are based on the epidemic toxin, which belongs to the heat toxin epidemic, with heat predominating over dampness, and the signs of deficiency and blood stasis are not obvious. The disease is related to the five internal organs, but the initial condition is mostly in the stage of Weiqi, Early control of the disease can prevent its deterioration. Modern Chinese medicine thinking should be established, and the use of truncation therapy and detoxification and clearing away heat and dampness should be emphasized. combination decoction with intravenous injection and oral administration of proprietary Chinese medicines etc. under the premise of strictly grasping the indications for the use of antibiotics and antiviral drugs, supplemented by supportive treatment. Much attention should be paid to diet, daily living, and psychological adjustment. Conclusion Epidemic toxin as the foundation and heat predominating over dampness are the core pathogenesis of new coronavirus Pneumonia in Guangdong. Syndrome differentiation and treatment Should be guided by the Theory of treatment Individualized to Patient, Season and Locality.