Traditional Chinese medicine has accumulated rich theories and experience in the fight against the pestilence for thousands of years. After the outbreak of corona virus disease 2019, numerous traditional Chinese medicine practitioners went deep into the frontline of the fight against the epidemic, and made contributions to resolutely winning the battle against the epidemic. Based on the collected data, the author analyzed, generalized and summarized the characteristics of TCM epidemic prevention in sichuan from four aspects: epidemic situation, background, etiology and pathogenesis of TCM, and treatment. The neo-coronary pneumonia disease in Sichuan area is affected by the poison of wet poisoning and epidemic disease. Wet evil is lingering, and its pathogenic characteristic is to invade multiple parts of the human body. The disease location is mainly in the lung、spleen、and triple energizer, which can involve membranous、pericardium、liver and kidney, and wet images are obvious in clinical symptoms.The prevention and treatment of corona virus disease 2019 with traditional Chinese medicine in Sichuan follows the principle of " preventive treatment of disease"、" reinforcing vital qi "、" treatment in accordance with three categories of etiologic factors" and “resolving of dampness with aromatics throughout treatment ".