Objective:The active components of Huoxiang Zhengqi Decoction were collected, the effective components and mechanism of novel coronavirus pneumonia (COVID-19) were investigated through molecular docking and network pharmacology. Method：Through the calculation method based on ligand-protein interaction, remdesivir was used as a control drug to explore the potential anti-COVID-19 natural drug components of Huoxiang Zhengqi Decoction.The better docking components were selected to predict the pharmacological mechanism, and the pharmacological mechanism was preliminarily explored. Result：In this study, we screened 5 small molecular components with stronger binding ability to 3CLpro than that of remdesivir. Network pharmacology initially predicted that the antiviral pathway might affect viral replication through the Network pharmacology preliminarily predicted that the antiviral pathway might be through the PI3K-Akt signaling pathway to affect viral replication. signaling pathway. Conclusion：The components C1-C5 bind well to 3CLpro, and it is speculated that it may be a potential inhibitor of 3CLpro, which is worthy of further development and research and helps to provide theoretical guidance and experimental basis for the development of natural antiviral drugs.