［］ Objective: To investigate professor Yang Nizhi"s medication rules of diabetic kidney disease. Method: A total of 256 cases of outpatient of diabetic kidney disease were collected from Guangdong Hospital of Traditional chinese medicine from May 2007 to July 2017,and the data was analyzed by using the Traditional Chinese Medicine Big Data Intelligent Processing and Knowledge Service System for data mining．Interview with professor Yang Nizhi was executed and its process was recorded. Result: The utilization rate of 8 TCM herbs was more than 60 times, which were Milkvetch Root, White Atractylodes Rhizome, Dodder Seed, Asiatic Cornelian Cherry Fruit, Heterophylly Falsestarwort Root, Salvia Root, Peach Seed, Hirsute Shiny Bugleweed Herb, Chinese Angelica. According to conventional classification of Chinese materia medica,herbs with the higher rate were kidney-tonics and those for activating blood stasis. Heterophylly Falsestarwort Root-Yerba Detajo Herb, Salvia Root-Milkvetch Root, Chinese Angelica are commonly used as medicine suits. Rhubarb is a special medicine for chronic renal failure in the late stage of diabetic nephropathy. Taking "Replenishing Qi and Activating Blood" as the main line, it can be used on different stages of diabetic kidney disease. Conclusion: The article reviews the herbs, their compatibility and the relationship between drug-disease in Replenishing Qi and Activating Blood" method. It is suggested that Professor Yang Nizhi treats diabetic kidney disease with Replenishing Qi and Activating Blood" method, with proper compatibility and close relationship of medicines, which provides ideas and basis for further clinical research in the future.