The pathogenesis of chronic kidney disease is based on the principle of positive deficiency and evil reality, with a long course of disease, which eventually leads to loss of internal organs and blood stasis, which makes the disease difficult to heal. Dahuang Zhechong Pill is a classic prescription, which can promote blood circulation and remove blood stasis, nourish and moisturize dryness, and relieve toxins. Clinical studies have shown that Dahuang Zhechong Pill has good effects on Diabetic Nephropathy, Chronic Nephritis, Nephrotic Syndrome, and Chronic Renal Failure. It can reduce proteinuria, improve blood lipid metabolism disorders, increase plasma albumin, improve renal fibrosis and coagulation indexes, improve nutritional status, and delay the progress of renal insufficiency. Experimental studies have confirmed that Dahuang Zhechong Pill has many functions such as protecting podocytes, reducing proteinuria, reducing renal interstitial fibrosis, resisting inflammatory factors, and regulating lipid metabolism disorders.