As the core of the clinical application of traditional Chinese medicine, four sex theory has played a great role in the clinical application and medical practice of traditional Chinese medicine. Four of the traditional Chinese medicine mainly refers to the temperature and cool properties, temperature and heat, cold and cold is essentially the same, with the same degree of resistance and other properties, can be used as a primary secondary resistance of traditional Chinese medicine. Whether the traditional Chinese medicine in the treatment of the disease the "fever" sex is also involved in the efficacy of the play? If there are feelings of body resistance "and" gene or protein group? According to the modern theory of traditional Chinese medicine and the temperature dependence of the transient receptor potential research, found that the traditional Chinese medicine and drugs and transient receptor potential correlation of temperature is closely related to the breakthrough of temperature dependence of transient receptor potential may be the theory of traditional Chinese medicine research.