目的 优选崔氏速效损伤灵药膏中续断、延胡索、红花、骨碎补合提的最佳提取工艺。方法 以川续断皂苷Ⅵ、延胡索乙素、羟基红花黄色素A、柚皮苷含量和出膏率为评价指标,采用AHP-CRITIC混合加权法确定各指标权重系数,多指标综合评分结合正交试验设计考察提取溶剂、料液比、提取时间、提取次数对提取效果的影响,优选崔氏速效损伤灵药膏中四味中药提取工艺。结果 优选得到最佳提取工艺条件如下：加10倍量70%乙醇,提取2次,每次1.5h。3批验证试验结果,综合评分均值为98.85,RSD为0.65%。结论 优选得到的提取工艺稳定可行,重复性好,可用于该制剂的工业化生产。
This study aimed to optimize the extraction technology of dipsacus asper Wall, Rhizoma corydalis, Carthamus tinctorius, Rhizoma drynariae in Cui-Shi quick-acting traumatic injury ointment. With the contents of Asperosaponin Ⅵ, tetrahydropalmatine, hydroxysaffor yellow A, naringin, and ratio of dry extraction as comprehensive evaluation indexes, The weight coefficient of each component was evaluated by AHP-CRITIC method. With composite score as index, the orthogonal experiment method was adopted to investigate the effects of the four factors including the extraction solvent, solid-liquid ratio, extraction time, and times on extraction process to optimize the processing technology of four Chinese medicine in Cui-Shi quick-acting traumatic injury ointment. The Optimal processing parameters were as follows: extracting 2 times with 10-fold of 70% ethanol, 2h for each time. The mean of three batches of comprehensive evaluation was 98.85% and RSD value was 0.65%. The optimized extraction technology is stable and feasible, which could be used for industrial production of the preparation.