目的 采用ALFF静息态磁共振分析技术探讨耳甲电针对抑郁症患者脑部神经元自发活动的调节作用。方法 纳入15例轻中度抑郁症患者，进行8周的耳甲电针治疗，并于治疗前后采集汉密尔顿抑郁量表（HAMD-17）评分及静息态功能磁共振扫描数据，评估耳甲电针抗抑郁的疗效，同时采用低频振幅算法对患者静息态功能磁共振数据进行分析，探讨耳甲电针对患者局部脑区神经元自发活动的调节作用。 结果 经过8周治疗后，患者HAMD-17量表评分降低（5.33 ± 2.19）；左侧的颞叶下回ALFF值升高，而右侧海马、楔前叶、距状裂周围皮质、左侧后扣带回和右侧丘脑ALFF值降低。结论 耳甲电针可有效改善患者的抑郁症状，对脑默认网络、情绪回路、认知和视觉相关皮质的脑区的自发神经元活动的调节作用可能是其抗抑郁的重要机制。
Objective To investigate the changes of spontaneous brain activity in depression disorder’s patients after the treatment of electro-auricular acupuncture by using Resting State Functional Magnetic Resonance Imaging (fMRI) and amplitude of low frequency-fluctuation (ALFF) analysis.Methods A total of 15 mild and moderate depressive patients underwent eight weeks of electro-acupuncture therapy. Patients were assessed by Hamilton Depression Scale (HAMD-17) analysis and BOLD-fMRI scan before and after the treatment. Both HAMD-17 score and BOLD-fMRI results were used to evaluate the efficiency of electro-acupuncture therapy as an antidepressant. Furthermore, the ALFF method was used to probe into the regulation of spontaneous brain activity by the electro-acupuncture therapy.Results After the treatment, patients HAMD-17 score were reduced (5.33 ± 2.19). Patients experienced a higher ALFF value in left inferior temporal gyrus, lower ALFF value in the right hippocampus, precuneus, peritalus cortex, left posterior cingulate gyrus and the right thalamus after the treatment.Conclusion Electro-auricular acupuncture shown efficacy in remission of depression disorder. We believe that the regulation in spontaneous activity of default mode network, emotional circuit as well as cortex relevant to cognitive and visual is the key mechanism of electro-auricular acupuncture.