熊果酸( ursolic acid，UA) 是广泛存在于夏枯草、女贞子等多种药用植物中的一种五环三萜类化合物，具有多种生物学效应。代谢综合征是以胰岛素抵抗为主，包括血脂异常、高血压、高血粘、葡萄糖稳态失调等为特征的一类代谢障碍疾病，已经成为严重的世界性健康问题。体内外研究表明，熊果酸对正常细胞毒性低，可有效改善糖脂代谢紊乱，提高胰岛素敏感性，调节代谢相关酶类的表达，进而改善肥胖、动脉粥样硬化、糖尿病以及延缓NAFLD进展等，且对正常细胞毒性低，是一种理想的天然抗代谢综合征候选药物。现综合国际文献报道，对熊果酸对代谢综合征的作用研究进展进行综述。
Ursolic acid is a naturally plant-derived pentacyclic triterpenotid that is commonly found in various medicinal herbs and fruits, which attracted clinical interest due to its various beneficial pharmacological properties. Metabolic syndrome is a kind of metabolic disorder characterized by insulin resistance, dyslipidemia, hyperviscosemia and glucose homeostasis，which is a serious global problem of public health. An increasing amount of evidence in vivo and in vitro have shown that ursolic acid has low cytotoxicity to normal cells, but can effectively modulate a set of pathological symptom of metabolic syndrome like dyslipidemia and insulin resistance, regulate the activity and expression of metabolism-related enzymes, thereby delay the progression of abdominal obesity, atherosclerosis, diabetes and NAFLD. It is a potential natural candidate drug for anti-metabolic syndrome. This review focuses on some of the most recent researches that demonstrate the anti-metabolic syndrome effect and mechanism of ursolic acid.