The side effects of acute and chronic nephrotoxicity of cyclosporine A are obvious. although the nephrotoxicity of cyclosporine A is dose-and concentration-dependent, nephrotoxicity may still occur when the blood concentration of CsA is in the normal treatment range. The main nephrotoxicity is renal fibrosis. the degree of lesion is closely related to the deterioration of renal function and the prognosis of chronic kidney disease. at present, there is no direct and effective method to prevent and treat it. Professor Huang Chunlin adopts the dialectical thinking of taking image ratio and examining syndrome and seeking causes in modern traditional Chinese medicine. through the combination of pathogenesis and pathology, he judges the TCM drug attribute and nephrotoxicity mechanism of CsA, and clinically uses Fangji Huangqi decoction and Wuzi Yanzong pills to add and subtract treatment. It can enhance the blood concentration of CsA and reduce its dosage, at the same time, it can prevent and treat renal fibrosis caused by CsA, give full play to the unique advantages of traditional Chinese medicine, and provide a sufficient theoretical basis for clinical practice.