The more data-oriented medical data in the Internet era is, the huge clinical data will have great research value. This paper aimed to introduce the application of big data in traditional Chinese medicine and the theory of big data application, only to provide more ideas for clinical research of Chinese medicine. In order to summarize the current status of data mining research in traditional Chinese medicine research, the Chinese Knowledge Network database was accurately searched, and 135 qualified documents supported by the National Natural Science Foundation of China were selected according to the inclusion and exclusion criteria. The publication time, research objects, research methods, and the results of the study were compared and analyzed. The results showed that data mining technology was widely used in traditional Chinese medicine research, and it can study Chinese medicine from multiple angles, multiple spaces and multiple factors, but there were still many shortcomings. Finally, the paper looked forward to the clinical application of big data of Chinese medicine, and proposed the positive impact of new application technologies such as Chinese medicine market, Chinese medicine clinical evaluation tools and real-world evidence theory on the clinical integration of big data and traditional Chinese medicine.