目的 通过挖掘中药复方专利中治疗抑郁的用药规律，为中药新方研发和临床应用提供参考。方法 登录中国专利公布公告网站，检索治疗抑郁的中药复方专利数据，采用中医传承辅助平台（V2.5）建立数据库，并对其进行频次统计、关联规则、复杂网络及熵层次聚类分析。结果 纳入2003年－2018年治疗抑郁的中药复方专利343项，涉及药物685味，最常用单味药为柴胡，高频药物归经以心、肝两经为主，功效多为安神、补气、活血、理气；最常用药对为白芍-柴胡，最常用角药为当归-白芍-柴胡；置信度最高的关联规则为“甘草，当归，茯苓→柴胡”；核心药物为柴胡、白芍、郁金、茯苓、甘草等; 熵层次聚类分析得到核心组合20个，新处方10首。结论 治疗抑郁的中药复方专利中常见证型为“肝郁脾虚证”，以疏肝解郁健脾为主要治则，同时根据症状辅以安神、益气、理气、活血、燥湿、清热等治法，多以逍遥散为基础方，常配伍心、肝两经药。
Objective To provide references for research and development of new TCM and clinical application by analyzing the medication and compatibility rules of compound TCM patents for treatment of depression.Methods Log in to the China Patent Announcement website to search for the patent data of TCM compound for treating depression. A database using TCM Auxiliary Inheritance Platform (V2.5) was established, and the frequency statistics, association rules, complex network, entropy clustering method were conducted.Results Totally 343 compound TCM patents from 2003 to 2018 for the treatment of viral myocarditis were included, involving 685 kinds of Chinese materia medica. The most common Chinese herbal medicine was Radix Bupleuri. The common Chinese herbal medicines were mainly heart and liver meridian tropism, which can be used to tranquilization, tonify qi, activating blood and regulating qi. The most common medical combination was Radix Paeoniae Alba - Radix Bupleuri. The most common triple combination was Radix Angelicae Sinensis - Radix Paeoniae Alba - Radix Bupleuri. Confidence-based association rule was “Radix Glycyrrhizae, Radix Angelicae Sinensis, Poria→Radix Bupleuri”. The core Chinese materia medica were Radix Bupleuri, Radix Paeoniae Alba, Radix Curcumae, Poria, Radix Glycyrrhizae. We found 20 drug combinations and 10 new prescriptions by the way of entropy clustering method.Conclusion In TCM patents for treatment of depression, the most common syndrome was deficiency of liver-stagnation and spleen-deficiency syndrome, mainly using treatment of soothing liver and strengthening spleen, meanwhile, flexibly using medicines for tranquilization, tonifying qi, regulating qi, activating blood, eliminating dampness and clearing heat according to symptoms, and the main prescription is Xiaoyao Powder, adding the medicines whose channel tropism are heart and liver.