Objective: To explore the effect of reducing phlegm and resolving masses on cytokines expression of Th2 cell in Graves&amp;quot;s disease (GD) mice. Methods: GD model was established by immunizing BALB/c female mice with recombinant adenovirus Ad-TSHR289 three times at 1th,4th,7th week. At 10th week, GD model mice were randomly divided into Model group, Methimazole group and Reducing phlegm and resolving masses group. Another normal mice of the same age were set as control group, 8 mice in each group were given intragastric administration for 6 weeks. The levels of TRAb and T4 in serum were detected by radioimmunoassay. The morphological changes of thyroid tissue were observed by HE staining and the differences of Th2 cell related factors were detected by Luminex liquid suspension chip. Results: Compared with the Normal group, T4 and TRAb in the Model group increased significantly (P &amp;lt; 0.001) and the morphological changes of follicular epithelial cell proliferation and intrafollicular convexity were observed under HE staining microscope. The T4 and TRAb of the Reducing phlegm and resolving massed and Methimazole group were lower than those of the model group (P &amp;lt; 0.05). The morphology of thyroid tissue in Reducing phlegm and resolving masses was significantly changed compared with that in Model group, while that in Methimazole group was not changed significantly. The levels of IL-6, IL-10 and IL-13 in the model group were significantly higher than those in the normal group (P &amp;lt; 0.05). Compared with Model group, the levels of IL-6, IL-10 and IL-13 in the reducing phlegm and resolving masses and Methimazole group were decreased. Moreover, the level of IL-6, IL-13 in reducing phlegm and resolving masses group and IL-6 in methimazole group were significantly lower than those in the model group (P &amp;lt; 0.05). Conclusion: the method of resolving phlegm and dispersing stagnation can improve the thyroid function and histomorphology of GD mice, meanwhile reducing the expression of Th2 cytokines IL-6, IL-10 and IL-13 which related with Th2 cell.