The concept of iron death was first proposed in Cell magazine. It was defined as a novel cell death pattern caused by iron peroxide-dependent lipid peroxide formation. Iron death is the damage mechanism of some nervous system diseases such as AD and PD. Iron ions accumulate in the process of cancer development, and leading to ferroptosis is a new target of cancer treatment. In this paper, the mechanism of ferroptosis and the research progress of the diseases are introduced systematically, which provide new ideas for the research on pathogenesis of diseases and clinical drug targets.