摘 要：目的 探讨揿针对肿瘤抑郁造模小鼠血清学及海马结构的影响。方法 选取健康雄性昆明小鼠45只小鼠均在其腹腔内注射S180瘤株，制备肿瘤模型。肿瘤造模成功后，肿瘤小鼠均进行为期14天的慢性不可预知温和刺激（CUMS）抑郁造模，造模成功后，按随机数字表法分为揿针组、传统针灸组，肿瘤抑郁造模组，以5只健康雄性昆明小鼠作为正常对照，集体饲养。揿针组、传统针灸组均针刺“百会”、“印堂”干预14天。2周后观察小鼠海马结构改变，酶联免疫吸附（ELISA）法测定小鼠血清五羟色胺（5-HT）和肾上腺素(EBI)水平。结果 与模型组相比，传统针灸组、揿针组均能提高小鼠血清中的5羟色胺含量，有统计学意义(P&amp;amp;lt;0.01)，且两组均能降低其肾上腺素(EBI)含量，有统计学意义(P&amp;amp;lt;0.01)，但揿针组小鼠的两项血清学含量水平低于传统针灸组小鼠的水平。揿针和传统针灸组小鼠海马结构得到改善。结论 揿针能够改善肿瘤抑郁模型小鼠抑郁状态及海马结构，但是改善的疗效次于传统针灸组的疗效，两者联合能够起到事半功倍的疗效。
Abstract: Objective: To explore the effectiveness of thumbtack therapy influencing the serums and hippocampus of mice. Method:45 mice were injected S180 tumor rood in their abdominal cavity, to conduct the tumor model. All assigned mice were accepted the chronic unpredictable mild stress（CUMS）during 14 days, then randomized to design the thumbtack therapy group, TCM acupuncture therapy group, and tumor-depression model group, mice in each group were accepted difference stimulated with two points-Baihui and Yingtang for 14 days, to estimate the change of the serology and hippocampus of mice. Results: To comparing with the modal group, there were significantly differences for 5-hydroxytryptamine in the thumbtack therapy group and acupuncture therapy group(P&amp;amp;lt;0.01)，as well as the same significantly difference for adrenaline in the listed both group when comparing with the modal group(P&amp;amp;lt;0.01)，however, the listed two indicts of serology in thumbtack therapy group was lower than one in acupuncture group, the structure of the hippocampi were improved in the listed stimulated groups. Conclusion: the thumbtack therapy can relieve the cancer-related depression, also to repair the structure of hippocampi.