缺血性卒中 MMP-1 MMP-3 痰热证

目的：研究缺血性中风病急性期痰热证患者与MMP-1和MMP-3表达的相关性,探讨MMP-1和MMP-3与中风病急性期痰热证是否存在相关性,其相关性研究能否形成微观辨证的依据。方法：筛选发病7天内就诊于中国中医科学院西苑医院的缺血性中风痰热证患者45名,非痰热证44名,对每例患者分别作出内风证、内火证、痰湿证、血瘀证、气虚证和阴虚证的量化诊断,并用ELISA法检测血清中MMP1和MMP-3的含量。结果：痰热证组和非痰热证组MMP-1和MMP-3的表达均无明显差异。结论：MMP-1和MMP-3不能作为痰热证的微观指标,需进一步寻找微观指标对中风病痰热证证候诊断及疗效评价提供更加客观支持。

the Acute Stage of Stroke MMP-1 MMP-3 Phlegm Heat Syndrome

Abstract: Objective: To investigate the relationship between the phlegm heat syndrome during the acute stage of stroke and the MMP-1 and MMP-3 expression, explore whether MMP-1 and MMP-3 are correlated with the phlegm heat syndrome during the acute stage of stroke, and find whether correlation studies can provide evidence for microcosmic syndrome differentiation. Methods: 45 patients with phlegm heat syndrome of ischemic stroke and 44 patients without phlegm heat syndrome who visited Xiyuan Hospital of China Academy Of Chinese Medical Sciences within 7 days after the onset were enrolled, brain doctors quantitatively diagnosed each patient with endogenous wind syndrome, endogenous fire syndrome, phlegm dampness syndrome, blood stasis syndrome, qi deficiency syndrome or yin deficiency syndrome syndrome with yin asthenia by using the Diagnostic Scale for TCM Syndromes of Ischemic Stroke, and detected the content of MMP1 and MMP-3 in serum by means of the ELISA method. Results: The patients in the phlegm heat group had not difference on MMP1 and MMP3 expression when compared with the non-phlegm heat group. Conclusion: the patients with phlegm heat syndrome at the acute stage of stroke had not different expression of MMP1 and MMP3, without providing the research basis for the microcosmic indicators of phlegm heat syndrome and further researching more objective supports to the diagnosis of phlegm heat syndrome of stroke and the efficacy evaluation.

中国博士后科学基金