This work aimed to assess the concordance of information collected by the TCM four diagnostic methods and diagnosis. 16 TCM experts were invited from Longhua Hospital, Shuguang Hospital, and Yueyang Hospital of Shanghai University of Traditional Chinese Medicine, and randomly selected 1 patient. They recorded patient information by the TCM four diagnostic methods and diagnosis. 25 cases were randomly selected, and 2 copies were made from the numerical data collected through the Inquiry Scale for Diagnosis of Heart System Syndromes developed by our research team. The copies were disorganized and renumbered from 1 to 50. In order to evaluate the concordance of successive diagnosis by the same clinician, 2 TCM experts were invited to differentiate the syndrome and diagnose for the 50 cases by the double-blind method. 15 cases were randomly selected. Three TCM clinicians were invited to make a diagnosis based on Zangfu-organs syndrome differentiation. The Kappa test was adopted. The results of experts judgement for the same patient showed that 9 experts judged red tongue, with the concordance being 56%, 9 experts judged deep pulse, with the concordance being 56.2%, and the concordance of deficiency syndrome was 89%. The results of successive diagnosis by the same clinician showed that the Kap concordance coefficient for the syndrome of deficiency of heart qi was 0.69, that for the syndrome of deficiency of heart yang was 0.80, and that for the syndrome of turbid phlegm was 0.78. The results of diagnosis by different clinicians showed that the Kap concordance coefficient for the syndrome of deficiency of heart qi was 0.63, that for the syndrome of deficiency of heart yang was 0.72, and that for the syndrome of deficiency of heart yin was 0.48. Taken together, diagnosis by the same clinician and different clinicians varied, indicating a poor concordance of the TCM four diagnostic methods and diagnosis.